From Mark Smith on the Surf ‘n Circuits blog:

Optimizing the 5v to 170v Nixie Tube Power Supply Design

A few years ago, while managing the power management product line at work, I started an initiative with the development team to optimize new products by achieving ESE.  ESE stands for Equations = Simulations = Experimentation.   The idea is centered on the engineering goal of product design to verify that the systems design equations match the simulation results and ultimately the experimental results.
When these three items match, not only do you understand a system, but you have the best chance to optimize a better solution.  I’ll have to say that in today’s mad dash to get new products out the door, achieving ESE is not always possible.    But to break through the ordinary and have a chance for the extraordinary, I would say this is a requirement.    Since this power supply is just a fun design for an upcoming nixie tube clock project of mine, I have the time to achieve ESE.

The updated schematic, BOM, Kicad Layout, and design files are located at Github:

surfncircuits has shared the board on OSH Park:

NixieSupply5vto160vDCMBoost_Rev2_1804

Here is a quick video showing six IN-4 Nixie tubes being powered by a 5v iPhone charger:

https://videopress.com/v/9tb9rW3s