Detailed setup instructions on the GitHub project page, including flashing latest MicroPython firmware, uploading game via WebREPL, display testing and of course, the game.
Conway's Game of Life on a Nokia 5110 with WeMos D1 mini running MicroPython ESP8266
My Arduino version using Adafruit library runs MUCH faster. https://github.com/mcauser/WeMos-D1-mini-Nokia-5110-PCD8544/blob/master/examples/conways-game-of-life/conways-game-of-life.ino