After long day working, finally I got successful making Nixie clock with Arduino and opto-isolation chip, no need Nixie driver which is difficult to purchase.
Details
My full instruction video about making Nixie clock with Arduino and Opto-isolation chip only.
The circuit uses opto-isolation chip to control Nixie tube (using 150VDC) by Arduino (using 5VDC). By matrix connection, so we need only 16 outputs from Arduino to control 60 lights of 6 nixie tube.
The real time clock module DS3231 is used to keep the time (even turn off power), it is communicated with Arduino by I2C network.
Arduino will read real time, then turn on/off nixie lights by sequence in high frequency to make human eyes view 6 numbers as permanent
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Arduino Code
Basically, the code will get real time from module DS3231 and show to 6 nixie tube via opto-isolation chip.