The CH375 modules available off ebay generally follow a common pinout and have a jumper to switch between serial and 8bit mode. The 8bit bus interface looks exactly like the 8080/Z80 style bus and the only logic on the adapter itself is the chip select generation.
Note that the port defaults to 0xFF and the jumpers set bits of the address to zero. As most adapters work the other way this makes it easy to slot these into other bits of the I.O map. The Fuzix drivers expect the device on 0xBE/0xBF (bottom but one jumper installed only).
The current driver just uses the block device mode on the CH375/6 so it's actually a tiny tiny piece of code. Some day I might try doing full USB. Someone was doing that for the Tandy COCO3 with NitrOS9 but I've not heard anything recently about how it is going