I propose starting from an existing CP/M-8000 machine project, which looks like this:

My project proposal is to

• construct on a Eurocard (160x100 mm)
• replace multiple TTL chips with GAL chips
• add a FIFO-interface USB module (replacing the Z8530 UART and serial USB module)
• add an STEbus interface

4sun5bu's sparsely-populated board has about 48x84 holes and looks about 5.4x9.25 inches or 235x137 mm. This is twice the area of a 160x100mm eurocard. I think it should fit.

4sun5bu says that 74F logic should be used, because 74LS is not fast enough.
I shall take that as a warning to pay attention to timing.

The Compact Flash interface is unbuffered. 
You might be able to use an IDE/PATA drive 
with a very short cable, not the long cables used in old PCs.

I intend to port some or all of the glue logic to GAL chips.
This will make changes quicker than rewiring.

Parts list:

Qty Device Package Comment

1 Z8001 DIP48 Essential
2 RAM DIP32 Essential
1 USB DIP24/40 Replaces Z8530 serial chip 
1 ATmega164 DIP40 Controls boot-up