The first prototype boards came back with the new layout for the TLV61225 boost converter.

With a bench supply, the old NCP1402 based boards took 30 µA. Under the same circumstances, the TLV61225 based board takes 80 µA. That's no good.

The good news is that the TPS61221 is pin-compatible with the TLV61225, so I'll give that a try. I'll be satisfied if the draw is under 50 µA even if it's not quite all the way down to 30 µA.